Symbol Name ID |
Lig4
ligase IV, DNA, ATP-dependent MGI:1335098 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Pancytopenia |
Anemia |
Acute lymphoblastic leukemia |
Thrombocytopenia |
Multiple myeloma |
Myelodysplasia |
Splenomegaly |
Hepatosplenomegaly |
Disease(s) Associated with LIG4 | ||||||||||||
DNA ligase IV deficiency | ||||||||||||
multiple myeloma | ||||||||||||
pancreatic cancer |
Mouse Phenotypes | hematopoietic system phenotype |
increased T cell apoptosis |
decreased T cell proliferation |
abnormal thymus morphology |
decreased thymus weight |
small thymus |
decreased thymocyte number |
abnormal lymphopoiesis |
abnormal B cell differentiation |
abnormal class switch recombination |
arrested B cell differentiation |
abnormal T cell differentiation |
abnormal T cell receptor V(D)J recombination |
abnormal T cell receptor beta chain V(D)J recombination |
decreased double-negative T cell number |
decreased double-positive T cell number |
arrested T cell differentiation |
decreased bone marrow cell number |
abnormal proerythroblast morphology |
abnormal lymphocyte cell number |
decreased B cell number |
increased NK cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased central memory CD8 positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
absent CD8-positive, alpha-beta T cells |
increased CD8-positive, alpha-beta T cell number |
decreased lymphocyte cell number |
decreased hematopoietic stem cell number |
abnormal regulatory T cell morphology |
decreased spleen weight |
small spleen |
decreased splenocyte number |
abnormal B cell activation |
decreased IgA level |
decreased IgD level |
decreased IgG2b level |
decreased IgG3 level |
decreased IgG level |
decreased IgM level |
decreased immunoglobulin level |
abnormal T cell activation |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||
Lig4m1Btlr/Lig4m1Btlr | |||||||||||||||||||||||||||||||||||||||||||||
Lig4m2Btlr/Lig4m2Btlr | |||||||||||||||||||||||||||||||||||||||||||||
Lig4tiny/Lig4tiny | |||||||||||||||||||||||||||||||||||||||||||||
Lig4tm1Fwa/Lig4tm1Fwa | * | ||||||||||||||||||||||||||||||||||||||||||||
Lig4tm2.1Fwa/Lig4tm2.1Fwa | |||||||||||||||||||||||||||||||||||||||||||||
Lig4tm3.1Fwa/Lig4tm3.1Fwa Tg(Cr2-cre)3Cgn/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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